Plica Syndrome 

By Jesse L. Pace, DO and Asheesh Bedi, MD

Plica syndrome is often characterized by anterior knee pain, which is most commonly found along the superomedial aspect of the knee. The “plica” is due to remnant embryological tissue that compartmentalizes the knee during fetal development. The plica is considered a “vestigial” structure, which means that it has lost its ability to function over time and does not functionally affect an individual whether it is present or absent. It has been likened to the appendix, which can be a source of pain but lacks significant important functions. 



Usually plica syndrome is characterized by pain near the anteromedial (in front and toward the midline) side of patella (kneecap). Usually the pain is associated with bending of the knee and is irritated after and during exercise. Usually, no other symptoms other than pain is present, but it can occasionally be accompanied by swelling of the knee after prolonged physical activity.


Diagnosis for plica syndrome

Plica syndrome is a difficult diagnosis in athletes, and is often made after “exclusion” of other common, structural causes of knee pain. Athletes will typically complain of discomfort along the front or inside of the knee. Usually there are no “mechanical symptoms” of locking or catching with a plica, but a sense of snapping or catching from a large plica can rarely occur. There may be tenderness in the region of the plica or medial femoral condyle where the plica is abrading the bone. Plain x-rays are usually normal. An MRI may show the plica on certain views, but is primarily useful to exclude bone bruises, meniscus tears, ligament injuries, and cartilage defects that can also cause similar pain and swelling of the knee joint. Routine labs are not beneficial to diagnose plica syndrome, but can help to identify other potential causes of knee pain.


Causes of plica syndrome 

Most often plica syndrome is precipitated by a history of blunt trauma to the front of the knee or prolonged strenuous exercise. The plica is an embryologic remnant that is present throughout life, but is believed that a traumatic event or repetitive microtrauma is responsible for inciting inflammation and symptoms.


Nonoperative treatment  

Usually the first line of treatment for plica syndrome in athletes includes rest from strenuous or precipitating activities. Physical therapy can be initiated to strengthen and stretch the muscles and soft tissues around the knee. In addition, oral non-steroidal anti-inflammatory medications and steroid injections can help alleviate the symptoms of plica syndrome by decreasing inflammation and synovitis. If symptoms of pain and swelling completely resolve, a gradual rehabilitation program is started with a controlled return to competition. Steroid injections should be used judiciously, however. Occasionally, athletes may have a “flare” reaction after the injection with increased pain and swelling in the knee joint that resolves after 48 to 72 hours. Diabetics may have to monitor their blood sugar levels more closely due to a risk of hyperglycemia. In addition, there is a small risk of local “fat atrophy” and slight skin discoloration at the site of the injection.


Surgery options

Failure to respond to months of nonoperative management may be an appropriate indication for surgical treatment in athletes. This procedure can be performed in a minimally invasive fashion (“arthroscopically”), using a camera and small instruments to excise the plica and associated inflammatory tissue around it that is causing the pain. The arthroscopic procedure also offers the benefit of allowing a thorough inspection of the knee for any other injuries or offending structures that may be a source of pain in athletes. The procedure has been reported with successful outcomes, allowing athletes to return to their previous level of competition without discomfort. However, the accurate diagnosis of a symptomatic plica remains the predominant challenge – not its surgical treatment. Many athletes will have asymptomatic plicas on imaging studies or arthroscopy that may not be the predominant cause of knee pain.


Return to play after surgery 

Arthroscopic surgery and plica excision is a relatively minor surgery. Unless associated procedures or repairs to knee ligaments or cartilage are required, a controlled rehabilitation program and quadriceps strengthening usually allows for an expeditious return to play 4 to 6 weeks after surgery. 


Getting a Second Opinion

A second opinion should be considered when deciding on a high-risk procedure like surgery or you want another opinion on your treatment options.  It will also provide you with peace of mind.  Multiple studies make a case for getting additional medical opinions.

In 2017, a Mayo Clinic study showed that 21% of patients who sought a second opinion left with a completely new diagnosis, and 66% were deemed partly correct, but refined or redefined by the second doctor.

You can ask your primary care doctor for another doctor to consider for a second opinion or ask your family and friends for suggestions.  Another option is to use a Telemedicine Second Opinion service from a local health center or a Virtual Care Service.


SportsMD’s Second Opinion and Telehealth Service

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Please reach out to us at if you need help finding a top sports doctor for a second opinion or Telehealth appointment in NY, NJ or CT.

We’ll do our best to connect you with a top sports medicine doctor who specializes in your injury area.



Ewing, JW. Plica: Pathologic or Not? J Am Acad Orthop Surg 1993;1:117-121.

Post, WR. Anterior Knee Pain: Diagnosis and Treatment. J Am Acad Orthop Surg 2005;13:534-543.

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